Keqiang Ye Lab

1.Nie S; Li B; Wang M; Chen Z; Ren J; Li Z; Xu X; Qian Z; Xie Z; Han J; Zhang Z; Zhang Z; Zhu Y; Chen Z; Yang X; Ye K. Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease. Adv Sci (Weinh). 2024 Nov 21:e2409477. doi: 10.1002/advs.202409477. Online ahead of print. PMID: 39573918

2.Xiang J; Tang J; Kang F; Ye J; Cui Y; Zhang Z; Wang J; Wu S; Ye K. Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson's and Alzheimer's disease co-pathology and behavior impairments. Neuron. 2024 Aug 30:S0896-6273(24)00576-2. doi: 10.1016/j.neuron.2024.08.003. Online ahead of print.PMID: 39241780

3.Xiong J; Kang SS; Wang M; Wang Z; Xia Y; Liao J; Liu X; Yu SP; Zhang Z; Ryu V; Yuen T; Zaidi M; Ye K. FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice. Nat Commun. 2023 Oct 18;14(1):6577. doi: 10.1038/s41467-023-42282-7.PMID: 37852961

4.Xiang J; Tao Y; Xia Y; Luo S; Zhao Q; Li B; Zhang X; Sun Y; Xia W; Zhang M; Kang SS; Ahn EH; Liu X; Xie F; Guan Y; Yang JJ; Bu L; Wu S; Wang X; Cao X; Liu C; Zhang Z; Li D; Ye K. Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies. Cell. 2023 186 (16) 3350-3367. doi: 10.1016/j.cell.2023.06.004.

5.Xia Y; Xiao Y; Wang ZH; Liu X; Alam AM; Haran JP; McCormick BA; Shu X; Wang X; Ye K. Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice. Nat Commun. 2023 Sep 6;14(1):5471. doi: 10.1038/s41467-023-41283-w.PMID: 37673907 

6.Xiong J; Liao J; Liu X; Zhang Z; Adams J; Pacifici R; Ye K. A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin. Nat Commun. 2022 Aug 16;13(1):4820. doi: 10.1038/s41467-022-32435-5.

7.Chen G; Ahn EH; Kang SS; Xia Y; Liu X; Zhang Z; Ye K. UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. Adv Sci (Weinh). 2022 Mar;9(7):e2103396. doi: 10.1002/advs.202103396. Epub 2022 Jan 12.

8.Kang SS; Meng L; Zhang X; Wu Z; Mancieri A; Xie B; Liu X; Weinshenker D; Peng J; Zhang Z; Ye K. Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation. Nat Struct Mol Biol. 2022 Mar 24. 29(4):292-305.doi: 10.1038/s41594-022-00745-3.

9.Chen C; Liao J; Xia Y; Liu X; Jones R; Haran J; McCormick B; Sampson TR; Alam A; Ye K. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut. 2022 Jan 11:gutjnl-2021-326269. doi: 10.1136/gutjnl-2021-326269.

10.Xiong J; Kang SS; Wang Z; Liu X; Kuo TC; Korkmaz F; Padilla A; Miyashita S; Chan P; Zhang Z; Katsel P; Burgess J; Gumerova A; Ievleva K; Sant D; Yu SP; Muradova V; Frolinger T; Lizneva D; Iqbal J; Goosens KA; Gera S; Rosen CJ; Haroutunian V; Ryu V; Yuen T; Zaidi M; Ye K. FSH blockade improves cognition in mice with Alzheimer's disease. Nature. 2022 Mar. 603(7901):470-476. doi: 10.1038/s41586-022-04463-0.

11.Xia Y; Qadota H; Wang ZH; Liu P; Liu X; Ye KX; Matheny CJ; Berglund K; Yu SP; Drake D; Bennett DA; Wang XC; Yankner BA; Benian GM; Ye K. Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression. Sci Adv. 2022 Apr;8(13):eabj8658. doi: 10.1126/sciadv.abj8658. Epub 2022 Mar 30.

12.Jasmin M; Ahn EH; Voutilainen MH; Fombonne J; Guix C; Viljakainen T; Kang SS; Yu LY; Saarma M; Mehlen P; Ye K. Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. EMBO J. 2021, e105537, doi:10.15252/embj.2020105537.